Fungi kple dɔlékuiwo ƒe gota gome si léna ɖe nu ŋu, si woyɔna be “extracellular matrix” alo ECM, ƒe nɔnɔme le abe jelly ene eye wòwɔa dɔ abe ametakpɔnu kple eƒe go ene. Gake le numekuku aɖe si wowɔ nyitsɔ laa le magazine si nye iScience me, si Massachusetts Yunivɛsiti Amherst wɔ le nuwɔwɔ aduadu kple Worcester Polytechnic Institute me nu la, ne oxalic acid alo acid bɔbɔe bubuwo le nugbagbevi sue aɖewo ƒe ECM wɔa gel. Esi wònye be ECM wɔa akpa vevi aɖe le nusianu me tso dɔlékuiwutikewo ƒe dɔlélenutsiŋutete dzi va ɖo pɔmpi siwo xe kple atikewɔnuwo ƒe ɖiƒoƒo dzi ta la, alesi nugbagbevi suesuewo trɔa asi le woƒe gelũhɛ siwo léna ɖe wo nɔewo ŋui gɔmesese kpɔa ŋusẽ gã aɖe ɖe míaƒe gbesiagbegbenɔnɔ dzi.

Barry Goodell, si nye nugbagbevi suewo ŋuti nufialagã le Massachusetts Amherst Yunivɛsiti eye wònye agbalẽa ŋlɔla gãtɔ gblɔ be: “Metsɔ ɖe le nugbagbevi suewo ƒe ECM me ɣesiaɣi.” "Zi geɖe la, amewo bua ECM be enye gotagome ametakpɔnu si mewɔa dɔ o si kpɔa nugbagbevi suesuesuewo ta. Gake ate ŋu anye mɔ si dzi nunyiame kple enzymewo age ɖo le nugbagbevi suewo ƒe lãmenugbagbeviwo me kple esiwo dona le wo me hã."
Nusi wotsɔ blae la wɔa dɔ geɖe: eƒe ƒoƒo ɖe nu ŋu fia be nugbagbevi suesue ɖekaɖekawo ateŋu aƒo ƒu awɔ ƒuƒoƒo alo “biofilms”, eye ne nugbagbevi suesuesue siwo sɔ wɔ esia la, ateŋu axe pɔmpiwo alo aƒo ɖi atikewɔnuwo.
Gake ele be akpɔnɔa hã nate ŋu age ɖe eme: nugbagbevi sue geɖewo ɖea enzyme vovovowo kple metabolite bubuwo doa goe to ECM me, yia nusi wodi be yewoaɖu alo axɔ dɔlékuiwo me (abe ati gbegblẽ alo akɔtalãwo ƒe lãkusi ene), eye emegbe, ne enzymeawo wu woƒe dɔ nu ko la, nuɖuɖumeŋusẽ ƒe dɔa – trɔa nunyiamewo trɔna to ECM la dzi.
Esia fia be menye ametakpɔnu si mewɔa dɔ o koe ECM nye o; Le nyateƒe me la, abe alesi Goodell kple eƒe dɔwɔhatiwo ɖee fia ene la, edze abe ŋutete le nugbagbevi suewo si be woakpɔ woƒe ECM ƒe ʋeʋẽ dzi eye le esia ta eƒe gege ɖe eme dzi ene. Aleke wowɔa esiae?
Le fungiwo me la, edze abe oxalic acid, si nye aɖi si bɔ ɖe numiemie geɖe me le dzɔdzɔme nu ene, eye abe alesi Goodell kple eƒe dɔwɔhatiwo va kpɔe ene la, edze abe nugbagbevi sue geɖe zãa oxalic acid si woɖena tsɔ blaa carbohydrates ƒe gotagome ƒuƒoƒo ene. si wɔa nusi léna ɖe nu ŋu. , ECM si le abe jelly ene.
Gake esi ƒuƒoƒoa lé ŋku ɖe eŋu nyuie la, wokpɔe be menye ɖeko oxalic acid kpena ɖe ECM ŋu ko o, ke “ewɔa ɖoɖo ɖe” eŋu hã: zi alesi nugbagbevi suesueawo tsɔ oxalic acid geɖe kpe ɖe carbohydrate-acid tsakatsaka ŋui la, zi nenemae ECM la va nɔa ʋeʋẽm wu. Zi alesi ECM la va le ʋeʋẽm la, zi nenemae wòxea mɔ na molecule gãwo be woagage ɖe nugbagbevi suea me alo ado le eme o, evɔ molecule suewo ya gakpɔtɔ le ablɔɖe me gena ɖe nugbagbevi la me tso nutoa me eye wòtrɔna ɖe eŋu.
Nusi ŋu woke ɖo sia doa kplamatse dzɔdzɔmeŋutinunya me gɔmesese si nɔ anyi tso blema ke le alesi atike vovovo siwo fungi kple dɔlékuiwo ɖena dona tso nugbagbevi sue siawo me yia nutoa me ŋutɔŋutɔ ŋu. Goodell kple eƒe dɔwɔhatiwo do susua ɖa be le go aɖewo me la, ate ŋu ahiã be nugbagbevi suewo naɖo ŋu ɖe molecule sue ŋutɔwo ƒe dodo ŋu geɖe wu be woadze matriki alo lãkusi si dzi nugbagbevi suea nɔ te ɖo be wòatsi agbe alo axɔ dɔa dzi. Esia fia be molecule suewo ƒe dodo hã ate ŋu awɔ akpa gã aɖe le dɔléle dzɔdzɔ me ne enzyme gãwo mete ŋu to nugbagbevi suesuewo ƒe lãmenugbagbeviwo godo ƒe ƒuƒoƒoa me o.
Goodell gblɔ be: “Edze abe titinanya aɖe li si me nugbagbevi suewo ate ŋu akpɔ acid ƒe agbɔsɔsɔ dzi le be woatrɔ ɖe nɔnɔme aɖe koŋ ŋu, eye woalé molecule gã aɖewo, abe enzymewo ene, ɖe te, evɔ woana molecule suewo nato ECM la me bɔbɔe molecule siwo lolo ŋutɔ. Ŋutete sia si le ame ŋutɔ ƒe didi nu ate ŋu anye nu vevitɔ si ana woaɖu mɔxenu vevi siwo le dɔlékuiwutikewo zazã me dometɔ ɖeka dzi, elabena asitɔtrɔ le ECM ŋu be wòate ŋu age ɖe eme wu ate ŋu ana dɔlékuiwutikewo kple dɔlékuiwutikewo nawɔ dɔ nyuie wu.

Goodell gblɔ be: “Ne míete ŋu kpɔ aɖi suewo abe oxalate ene ƒe dɔwɔwɔ kple woƒe dodo le nugbagbevi suesue aɖewo me dzi la, ekema míate ŋu akpɔ nusiwo yia nugbagbevi suesueawo me hã dzi, si ate ŋu ana míate ŋu ada dɔlékui suesuewo ƒe dɔléle geɖe nyuie wu.”
Le December 2022 me la, nugbagbevi suesuewo ŋuti nunyala Yasu Morita xɔ gakpekpeɖeŋu tso Dukɔa ƒe Lãmesẽnyawo Gbɔkpɔha gbɔ be wòado alɔ numekuku siwo ƒe taɖodzinue nye mlɔeba be woato yɔmekpe ƒe atike yeye siwo wɔa dɔ wu vɛ.

Ne èdi nyatakaka bubuwo la, taflatse ɖo e-mail ɖem.
E-mail:
info@pulisichem.cn
Telefon:
+86-533-3149598 dzi