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Ðe aɖuɖɔtoetetedɔ bɔbɔe aɖe ate ŋu ade dzesi Alzheimer-dɔlélea ƒe gɔmedzedze, si aʋu mɔ na ame gbogbowo dodokpɔ ƒe ɖoɖowoa? Frontiers in Aging Neuroscience ƒe numekuku yeyea ɖe esia fia godoo. Numekulaawo do Alzheimer-dɔlélawo ƒe ƒuƒoƒo gã aɖe si ƒe sesẽme le vovovo eye wole lãmesẽ me siwo ƒe susu sɔ la kpɔ be woatsɔ ade dzesi vovototo siwo le aɖuɖɔ me dɔlékuiwo ƒe dzesiwo me.
Wokpɔe be formic acid si le aɖuɖɔ me nye dzesi vevi aɖe si fia be susu ƒe dɔwɔwɔ dzi ɖena kpɔtɔna le susu me eye ate ŋu aɖe gbeƒã Alzheimer ƒe dɔlélea ƒe gɔmedzedze. Mɔnu siwo li xoxo siwo dzi woato anya Alzheimer-dɔlélea xɔ asi, womesɔ o, eye womate ŋu ado wo kpɔ edziedzi o. Esia fia be ne etsi megbe akpa hafi woate ŋu awɔ atike na dɔnɔ akpa gãtɔ ko hafi wokpɔa dɔlélea le wo ŋu. Gake aɖuɖɔtoe me dodokpɔ si me womedea abi ame ŋu o, si mexɔ asi o, eye wòsɔ na formic acid ate ŋu anye nusi tututu ɖɔktawo le biabiam be woadoe kpɔ kaba.
Agbalẽa ŋlɔlawo gblɔ be: “Alzheimer ƒe dɔlélea nye dɔléle si nɔa anyi didi eye wònye ayemɔ, si fia be ate ŋu adze egɔme ahanɔ anyi ƒe geɖe hafi susu ƒe dɔmawɔmawɔ nyuie nadze ƒã.” "Dɔlélea ƒe gɔmedzedze dzɔna do ŋgɔ na tagbɔdɔ si womate ŋu atrɔ o, si nye sikafesre na nudede nyawo me kple edada. Eyata ehiã be woado ame tsitsiwo kpɔ le mɔ gã aɖe nu be woakpɔ Alzheimer-dɔléle si le gɔmedzedzea me."
Eyata ne nudede eme kaba le vevie la, nukatae míewɔa ɖoɖo siwo wowɔna edziedzi be míado Alzheimer-dɔlélea ƒe gɔmedzedze kpɔ o? Kuxia le dɔlélewo didi ƒe mɔnu siwo ɖɔktawo zãna fifia me. Esiawo dometɔ aɖewoe nye positron emission tomography of the brain, si xɔ asi eye wònaa dɔnɔwo kpɔa keklẽŋusẽ. Dodokpɔ siwo wotsɔ dea dzesi nugbagbeviwo hã li siwo ate ŋu ade dzesi Alzheimer dɔlélea, gake ebia be woaɖe ʋu le lãme na ame alo woaɖe akɔta be woakpɔ ahɔhɔ̃metsi, si ate ŋu anye be dɔnɔwo le hehem ɖe megbe.
Gake aɖuɖɔtoetetedɔ dodokpɔwo mewɔa nuvevi ame o eye wòsɔ, si wɔe be wosɔ nyuie na ame gbogbowo ƒe dodokpɔ. Togbɔ be numekulawo de dzesi Alzheimer ƒe dɔlélea ƒe dzesi siwo le aɖuɖɔ me va yi hã la, wo dometɔ aɖeke mesɔ be woatsɔ ade dzesi dɔlélea ƒe gɔmedzedze o, si fia be sikafesre si woatsɔ adae kaba la gakpɔtɔ nye nusi womate ŋu akpɔ o.
Numekula siwo le megbe na numekuku yeyea srɔ̃ nu tso lãmenugbagbeviwo ƒe atike aɖe si woyɔna be formaldehyde ŋu va yi be enye aɖuɖɔtoe me biomarker na Alzheimer ƒe dɔlélea. Gake mɔnukpɔkpɔ li be woawɔ ŋgɔyiyi le dɔlélewo didi kaba me. Le numekuku yeye sia me la, woƒe susu nɔ formate, si nye formaldehyde ƒe lãmenugbagbeviwo ƒe dɔwɔwɔ ŋu, be woakpɔe ɖa be ewɔa dɔ nyuie wu abe biomarker ene hã.
Ame 574 ye kpɔ gome le numekukua me, eye gomekpɔlawo nye lɔlɔ̃nu faa dɔwɔla siwo le lãmesẽ me le susu me alo dɔlélea ƒe ŋgɔyiyi le vovovo, tso susu ƒe ɖiɖi le susu me dzi va ɖo dɔléle keŋkeŋ dzi. Numekulaawo da aɖuɖɔ kple ʋu siwo woɖe tso gomekpɔlawo gbɔ kpɔ eye wowɔ susuŋutinunya me numekuku.
Numekukua ɖee fia be aɖuɖɔtoe me formic acid ƒe agbɔsɔsɔ dzi ɖe edzi ŋutɔ le Alzheimer ƒe dɔlélea ƒe hatsotsowo katã me eye wòdo ƒome kple susu ƒe dɔwɔwɔ ƒe ɖiɖi ne wotsɔe sɔ kple amesiwo le lãmesẽ me, siwo dome susu ƒe dɔwɔwɔ ƒe ɖiɖi le gɔmedzedzea me ƒe ƒuƒoƒoa hã le. Esia fia be formic acid ate ŋu anye biomarker si sea nu gɔme na Alzheimer ƒe dɔlélea ƒe gɔmedzedze.
Enyo be míade dzesii be esi numekulaawo ku aɖuɖɔtoe me formate ƒe agbɔsɔsɔ si wotsɔ kpe ɖe Alzheimer ƒe ʋumenugbagbeviɣi ƒe dzesiwo ŋu la, wokpɔe be yewoate ŋu agblɔ dɔlélea ƒe akpa si me tom dɔnɔa le la ɖi nyuie wu. Gake ehiã be woagawɔ numekuku bubuwo be woase kadodo si le Alzheimer-dɔlélea kple formic acid dome gɔme.
Agbalẽa ŋlɔlawo gblɔ be: “Aɖuɖɔ me formic acid ɖee fia be esea veve nyuie ŋutɔ ne wodo Alzheimer ƒe dɔlélea kpɔ kaba.” “Aɖuɖɔtoe me biomarker dodokpɔ hena Alzheimer ƒe dɔlélea sɔ eye mexɔa ga geɖe o eye ele be woatsɔe ade ame tsitsiwo ƒe lãmesẽ dodokpɔ siwo wowɔna edziedzi me.”
Wang, Y. kple ame bubuwo. (2022) Ðoɖowɔwɔ ɖe aɖuɖɔtoe me formic acid ŋu abe biomarker yeye si ate ŋu anye na Alzheimer ƒe dɔlélea ene. Liƒo siwo le tsitsi ƒe ahɔhɔ̃mekawo ŋuti nunya me. 10.3389/fnagi.2022.1046066.
Tags: tsitsi, Alzheimer ƒe dɔléle, biomarkers, ʋu, ahɔhɔ̃, dɔléle siwo nɔa anyi didi, siwo nɔa anyi didi, atikewo, tagbɔdɔléle, dɔlélewo didi, ɖɔktawo, formaldehyde, ahɔhɔ̃ŋutinunya, positron emission tomography, numekuku, tomography, aɖuɖɔtoe me dzodzro
Le Pittcon 2023 si wowɔ le Philadelphia, Pennsylvania la, míebia gbe Nufialagã Joseph Wang, amesi xɔ ƒe sia me ƒe Ralph N. Adams ƒe Dzɔdzɔmeŋusẽŋununya ƒe Nunana, tso alesi biosensor mɔ̃ɖaŋununya te ŋu wɔa dɔ vovovowoe ŋu.
Le gbebiame sia me la, míeƒo nu tso gbɔgbɔtsixe ƒe lãmenugbagbeviwo ɖeɖe kple alesi wòate ŋu anye dɔwɔnu nyui aɖe si woatsɔ asrɔ̃ nu tso biomarkers ŋu hena dɔléle didi kaba ŋu kple Mariana Leal, Team Leader le Owlstone Medical.
Abe míaƒe SLAS US 2023 ƒe numetoto ƒe akpa aɖe ene la, míedzro etsɔme ƒe dodokpɔxɔ kple alesi wòate ŋu anɔ me kple Luigi Da Via, GSK Test Development Team Lead.
News-Medical.Net naa atikewɔwɔ ŋuti nyatakakawo ƒe dɔwɔƒe sia le ɖoɖo kple nɔnɔme siawo nu. Taflatse de dzesii be woɖoe be atikewɔwɔ ŋuti nyatakaka siwo le nyatakakadzraɖoƒe sia nado alɔ dɔnɔa ƒe atikewɔla/atikewɔla ƒe ƒomedodo kple atikewɔwɔ ŋuti aɖaŋuɖoɖo siwo woate ŋu ana la, ke menye be woatsɔ aɖo eteƒe o.