Le nuŋɔŋlɔmetolawo ƒe mɔfiame sesẽ siwo ku ɖe nyatakakatsoƒewo tiatia ŋu nu la, míedoa ka kple agbalẽnyalawo ƒe numekukudɔwɔƒewo, nyadzɔdzɔgblɔmɔ̃ siwo ŋu ŋkɔ le, kple, le afisiwo wòle la, atikewɔwɔ ŋuti numekuku siwo me woto le hatiwo gbɔ ko. Taflatse de dzesii be xexlẽdzesi siwo le fli me (1, 2, kple bubuawo) nye kadodo siwo dzi woate ŋu azi atsɔ ayi numekuku siawo gbɔ.
Menye ɖe woɖoe be nyatakaka siwo le míaƒe nyatiwo me naxɔ ɖe ame ŋutɔ ƒe kadodo kple lãmesẽdɔwɔla bibi teƒe o eye womeɖoe be woazã wo abe atikewɔwɔ ŋuti aɖaŋuɖoɖo ene o.
Dzɔdzɔmeŋutinunya me kpeɖodziwo dzie wotu nyati sia ɖo, si eŋutinunyalawo ŋlɔ eye míaƒe nuŋɔŋlɔmetolawo ƒe ƒuƒoƒo si wona hehee la to eme. Taflatse de dzesii be xexlẽdzesi siwo le fli me (1, 2, kple bubuawo) tsi tre ɖi na kadodo siwo dzi woate ŋu akli atsɔ ayi atikewɔwɔ ŋuti numekuku siwo me hatiwo to me.
Míaƒe ƒuƒoƒoa me tɔwoe nye nuɖuɖuŋutinunyala kple nuɖuɖuŋutinunyala siwo woŋlɔ ŋkɔ na, ​​lãmesẽfiala siwo xɔ ɖaseɖigbalẽ, kpakple ŋusẽ kple nɔnɔmewɔwɔ ŋuti nunyala bibi siwo ŋu woɖo kpee, ame ŋutɔ ƒe hehenalawo kple kamedede ɖɔɖɔɖo ŋuti nunyala bibiwo. Menye numekuku tsitotsito koe míaƒe ƒuƒoƒoa ƒe taɖodzinue nye o, ke boŋ enye nyateƒetoto kple ameŋkumemakpɔmakpɔ hã.
Menye ɖe woɖoe be nyatakaka siwo le míaƒe nyatiwo me naxɔ ɖe ame ŋutɔ ƒe kadodo kple lãmesẽdɔwɔla bibi teƒe o eye womeɖoe be woazã wo abe atikewɔwɔ ŋuti aɖaŋuɖoɖo ene o.
Nusiwo wozãna wu le atikewo kple kpeɖeŋutɔtikewo me egbea dometɔ ɖekae nye magnesium stearate. Le nyateƒe me la, asesẽ na wò be nàkpɔ kpeɖeŋutɔ le asi me egbea si me mele o—eɖanye magnesium kpeɖeŋutɔ, nuɖuɖumeŋusẽ, alo kpeɖeŋutɔ bubu si nètia ŋue míele nu ƒom tsoe o—togbɔ be ɖewohĩ màkpɔ eƒe ŋkɔ tẽ o hã.
Zi geɖe la, woyɔnae be ŋkɔ bubuwo abe “amagbe stearate” alo nusiwo woɖe tso eme abe “stearic acid” ene, wokpɔnɛ le afisiafi kloe. Tsɔ kpe ɖe alesi magnesium stearate le afisiafi ŋu la, enye nusiwo ŋu woʋlia nya le wu le kpeɖeŋutɔ ƒe xexeame hã dometɔ ɖeka.
Le mɔ aɖewo nu la, esia sɔ kple nyaʋiʋli si ku ɖe vitamin B17 ŋu: ɖe wònye aɖi alo kansa ƒe atike. Nublanuitɔe na dukɔmeviwo la, zi geɖe la, dzɔdzɔmelãmesẽ ŋuti nunyalawo, kpeɖeŋutɔdɔwɔƒewo ƒe numekulawo, kple atikewɔlawo tsɔa kpeɖodzi siwo tsi tre ɖe wo nɔewo ŋu ɖoa kpe woawo ŋutɔ ƒe nukpɔsusuwo dzi, eye nyateƒenyawo xɔxɔ sesẽna ŋutɔ.
Anyo wu be nàwɔ nu wòasɔ le nyaʋiʋli mawo me eye nàɖɔ ŋu ɖo le nukpɔsusu siwo gbɔ eme ƒe akpa dzi nɔnɔ ŋu.
Nya lae nye esi: Abe alesi wòle le nusiwo wotsɔ yɔa nu me kple nusiwo nana wowɔa nu wòlolona ƒe akpa gãtɔ gome ene la, magnesium stearate meɖea vi le agbɔsɔsɔ gã me o, gake eɖuɖu megblẽa nu abe alesi ame aɖewo gblɔe ene o elabena zi geɖe la, agbɔsɔsɔ sue ŋutɔ koe woate ŋu akpɔe.
Magnesium stearate nye magnesium dze si le stearic acid me. Le nyateƒe me la, enye atike si me stearic acid kple magnesium ƒomevi eve le.
Stearic acid nye ami si me ami ʋeʋĩ le si le nuɖuɖu geɖe me, siwo dometɔ aɖewoe nye lãwo kple amagbewo ƒe ami kple amiwo. Kokoo kple flaxseed nye nuɖuɖu siwo me stearic acid sɔ gbɔ ɖo ƒe kpɔɖeŋuwo.
Ne wogamã magnesium stearate ɖe eƒe akpa siwo le ŋutilãa me vɔ la, ami si le eme la sɔ kple stearic acid kloe. Wozãa magnesium stearate powder zi geɖe abe nuɖuɖu kpeɖeŋutɔ, nuɖuɖutsoƒe kple kpeɖeŋutɔ le atsyɔ̃ɖonuwo me.
Magnesium stearate ye nye nusi wozãna wu le atikekuiwo wɔwɔ me elabena enye ami si wɔa dɔ nyuie. Wozãnɛ le atikekuiwo, atikekuiwo, kple nuɖuɖu geɖe hã me, siwo dometɔ aɖewoe nye akpɔnɔ viviwo, aŋenuwo, gbetikewo, nu ʋeʋĩwo, kple abolomenuwo.
Wonyae be “nu si sina toa eme” la, ekpena ɖe ewɔwɔ ŋu kabakaba to mɔxexe ɖe nusiwo wotsɔ wɔe nu be woagalé ɖe mɔ̃ɖaŋudɔwɔnuwo ŋu o me. Atike si wotsɔ tsakae si tsyɔa atike alo kpeɖeŋutɔ ƒe tsakatsaka ɖesiaɖe kloe dzi kple agbɔsɔsɔ sue aɖe ko.
Woateŋu azãe hã abe emulsifier, adhesive, thickener, anti-caking agent, ami, release agent kple defoamer ene.
Menye ɖeko wòɖea vi na ewɔwɔ to mɔɖeɖe be woatsɔ mɔ̃ siwo wɔa wo la dzi bɔbɔe o, ke ena wònɔa bɔbɔe be woami atikekuiawo ahazɔ to dɔgboa me hã. Magnesium stearate hã nye kpeɖeŋutɔ si bɔ, si fia be ekpena ɖe atike vovovo siwo wɔa dɔ ƒe atikewɔwɔ ƒe ŋusẽkpɔɖeamedzi ŋu eye wòdoa atikewo ƒe xɔxlɔ̃ kple woƒe ʋuʋu ɖe ŋgɔ.
Ame aɖewo gblɔna be yewote ŋu wɔa atikewo alo kpeɖeŋutɔ siwo kpena ɖe ame ŋu abe magnesium stearate ene manɔmee, si na wobia nya be nukatae wozãa wo ne dzɔdzɔmenu siwo woate ŋu azã ɖe wo teƒe geɖe wu li. Gake ɖewohĩ esia manɔ alea o.
Fifia wowɔa atike aɖewo kple atike siwo woate ŋu azã ɖe magnesium stearate teƒe tsɔ zãa dzɔdzɔme kpeɖeŋutɔwo abe ascorbyl palmitate ene, gake míewɔa esia le afisi gɔmesese le eye menye le esi míese dzɔdzɔmeŋutinunya gɔme vodadatɔe ta o. Gake menye ɣesiaɣie atike siawo siwo woate ŋu azã ɖe eteƒe la wɔa dɔ o elabena woƒe dzɔdzɔmenunɔamesiwo to vovo.
Fifia womenya nenye be woate ŋu aɖɔli magnesium stearate alo ahiã gɔ̃ hã o.
Anɔ eme be magnesium stearate mele dedie o ne woɖui le agbɔsɔsɔ si le nuɖuɖutikewo kple nuɖuɖutsoƒewo me. Le nyateƒe me la, èkpɔe dze sii alo mèkpɔe o, ɖewohĩ ètsɔa vitamin geɖe, akɔɖumi, azi kple tɔmelã kpena ɖe eŋu gbesiagbe.
Abe tomenu bubu siwo me chelated le (magnesium ascorbate, magnesium citrate, kple bubuawo) ene la, [eƒe] mekpɔa ŋusẽ gbegblẽ aɖeke le dzɔdzɔme nu o elabena mineral kple nuɖuɖu me acid (amagbe stearic acid si wotsɔ magnesium dzewo ɖa) ye le eme. Nusiwo mewɔa akpa aɖeke o siwo li ke ye le eme. .
Le go bubu me la, Dukɔa ƒe Lãmesẽnyawo Gbɔkpɔha (NIH) xlɔ̃ nu le eƒe nyatakaka si ku ɖe magnesium stearate ŋu me be magnesium si sɔ gbɔ ate ŋu agblẽ nu le ahɔhɔ̃mekawo ƒe dɔlékuiwo kaka ŋu eye wòana ame nagbɔdzɔ eye eƒe susu ƒe dɔwɔwɔ dzi naɖe akpɔtɔ. Togbɔ be esia mebɔ kura o hã la, Dukɔa ƒe Lãmesẽnyawo Gbɔkpɔha (NIH) ka nya ta be:
Dɔlékui akpe geɖe xɔa ame ƒe sia ƒe, gake ƒã hafi wòɖenɛ fiana vevie. Aɖi sesẽ dzɔna zi geɖe le ʋuka me ʋudodo gaƒoƒo geɖe megbe (zi geɖe le preeclampsia me) eye ate ŋu adzɔ le atike si wozãna wògbɔa eme ɣeyiɣi didi megbe, vevietɔ le ayiku ƒe dɔmawɔmawɔ nyuie ƒe nɔnɔme me. Woka nya ta be aɖi sesẽ aɖe le ame ŋu le eɖuɖu kpata megbe, gake ƒã ŋutɔ.
Ke hã, nyatakakaa meka ɖe edzi na amesiame o. Ne èlé ŋku ɖe Google ŋu kaba ko la, àkpɔe be magnesium stearate do ƒome kple eƒe nugbegblẽ le ame ŋu geɖe, abe:
Esi wònye be elɔ̃a tsi (“elɔ̃a tsi”) ta la, nyatakakawo li be magnesium stearate ate ŋu ana atikewo kple kpeɖeŋutɔtikewo ƒe ʋuʋu le dɔgboa me nagbɔdzɔ. Magnesium stearate ƒe ametakpɔnu kpɔa ŋusẽ ɖe ŋutilãa ƒe ŋutete be wòaxɔ atikewo kple nunyiamewo dzi tẽ, eye le nukpɔsusu nu la, esia wɔnɛ be viɖe aɖeke meganɔa atike alo kpeɖeŋutɔa ŋu ne ŋutilãa mete ŋu gblẽnɛ nyuie o.
Le go bubu me la, numekuku aɖe si Maryland Yunivɛsiti wɔ gblɔ be magnesium stearate mekpɔa ŋusẽ ɖe atike siwo propranolol hydrochloride, si nye atike si wozãna tsɔ léa dzi ƒe tsotso kple aɖuɖɔtoe me ʋuʋu nu la ɖena ɖe go dzi o, eyata adaŋudeha la gakpɔtɔ le gota le ɣeyiɣi sia me. .
Le nyateƒe me la, atikewɔlawo zãa magnesium stearate tsɔ naa atikekuiawo ƒe wɔwɔme dzina ɖe edzi eye wodoa atike la ƒe xɔxlɔ̃ nyuie ɖe ŋgɔ to emenuwo ƒe gbagbã hehe ɖe megbe vaseɖe esime wòaɖo dɔgboa me.
T lãmenugbagbeviwo, siwo nye ŋutilã ƒe dɔlélenutsiŋutete ƒe akpa vevi aɖe si dzea dɔlékuiwo dzi la, mekpɔa ŋusẽ ɖe magnesium stearate dzi tẽ o, ke boŋ stearic acid, si nye nu vevitɔ si le kpeɖeŋutɔ siwo bɔ me, kpɔa ŋusẽ ɖe wo dzi.
Woƒo nu tso eŋu zi gbãtɔ le ƒe 1990 me le magazine si nye Immunology me, afisi numekuku ɖedzesi sia ɖe alesi wotsia dɔlélenutsiŋutete ƒe ŋuɖoɖo siwo nɔa te ɖe T dzi nu le stearic acid ɖeɖeko ƒe anyinɔnɔ me fia le.
Le Japantɔwo ƒe numekuku aɖe si wowɔ tsɔ da kpeɖeŋutɔ siwo bɔ me la, wokpɔe be amagbewo me magnesium stearate ye nye nusi dze formaldehyde ƒe wɔwɔ gɔme. Gake ɖewohĩ esia mavɔ̃ɖi abe alesi wòdze ene o, elabena kpeɖodziwo ɖee fia be formaldehyde le atikutsetse yeye geɖe, amagbewo kple lãwo ƒe nuɖuɖu geɖe me le dzɔdzɔme nu, siwo dometɔ aɖewoe nye akɔɖu, akɔɖu, aŋanyi, kale, nyilã kple kɔfi gɔ̃ hã.
Be wò susu naɖe dzi ɖi la, magnesium stearate ye wɔa formaldehyde suetɔ kekeake le nusiwo katã wodo kpɔ dome: nanogram 0.3 le magnesium stearate gram ɖeka me. Ne wotsɔe sɔ kple esia la, shiitake-lã ƒuƒu ɖuɖu naa formaldehyde si wu miligram 406 le kilogram ɖeka si woɖu me.
Le ƒe 2011 me la, Xexeame ƒe Lãmesẽ Habɔbɔ ta nyatakaka aɖe si ƒo nu tso alesi wotsɔ atike siwo ate ŋu agblẽ nu le ame ŋu, siwo dometɔ aɖewoe nye bisphenol A, calcium hydroxide, dibenzoylmethane, irganox 1010 kple zeolite (sodium aluminum silicate) ƒo ɖi magnesium stearate ƒe hatsotso geɖe.
Esi wònye be esia nye nudzɔdzɔ si woɖe ɖe aga ta la, míate ŋu aƒo nya ta kaba be ele be amesiwo noa atike siwo kpena ɖe ame ŋu kple atike siwo woŋlɔ na wo siwo me magnesium stearate le la naɖɔ ŋu ɖo le aɖi ƒe ɖiƒoƒo ŋu o.
Ame aɖewo ate ŋu akpɔ nulɔdɔ ƒe dzesiwo ne woɖu atike alo kpeɖeŋutɔ siwo me magnesium stearate le, si ate ŋu ana aɖuɖɔtoe kple dɔgbo natsi. Ne atike siwo wotsɔ kpena ɖe nuɖuɖu ŋu gblẽa nu le ŋuwò la, ele be nàxlẽ nusiwo wotsɔ wɔa nuɖuɖua ƒe ŋkɔwo nyuie eye nàwɔ numekuku vi aɖe be nàke ɖe atike siwo wometsɔ kpeɖeŋutɔ siwo ame geɖe zãna wɔe o ŋu.
Dukɔa ƒe Nu Gbagbewo Ŋuti Mɔ̃ɖaŋununya Dɔwɔƒe kafui be woabu magnesium stearate mg 2500 le ame ƒe kpekpeme kilogram ɖeka me be ele dedie. Le ame tsitsi si ƒe kpekpeme anɔ abe kilogram 150 ene gome la, esia sɔ kple miligram 170,000 gbesiagbe.
Ne míele nusiwo magnesium stearate ate ŋu agblẽ le ame ŋu ŋu bum la, eɖea vi be woabu “agbɔsɔsɔme si dzi woanɔ te ɖo” ŋu. Ne míagblɔe bubui la, negbe agbɔsɔsɔ si wodona ɖe ʋuka me na dɔléle sesẽwo koe woɖee fia le nudokpɔƒe ƒe numekuku siwo me wozi sisiblisiwo dzi woɖui wògbɔ eme ale gbegbe be amegbetɔ aɖeke le anyigba dzi mate ŋu aɖu nu fũu nenema gbegbe o.
Le ƒe 1980 me la, magazine si nye Toxicology ka nya ta tso numekuku aɖe si me wona nuɖuɖu si wowɔ afã kple afã si me magnesium stearate 0%, 5%, 10%, alo 20% le sisiblisi 40 hena ɣleti etɔ̃ la me tsonu. Nusiwo ŋu wòke ɖoe nye esi:
Ele be míade dzesii be stearic acid kple magnesium stearate ƒe agbɔsɔsɔ si wozãna zi geɖe le atikekuiwo me la le sue ŋutɔ. Zi geɖe la, stearic acid nyea 0.5–10% le atikekui la ƒe kpekpeme nu, gake zi geɖe la, magnesium stearate nyea 0.25–1.5% le atikekui la ƒe kpekpeme nu. Eyata stearic acid si ade mg 25 kple magnesium stearate si ade mg 5 ate ŋu anɔ atikekui si ƒe kpekpeme nye mg 500 me.
Nusianu ƒe agbɔsɔsɔ fũ ate ŋu agblẽ nu le ame ŋu eye amewo ate ŋu aku le tsi nono fũ ta, alo? Esia le vevie be míaɖo ŋku edzi elabena hafi magnesium stearate nagblẽ nu le ame aɖe ŋu la, ahiã be woano atikekui/atike akpe geɖe gbesiagbe.